USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: NDKB_HUMAN USC-OGP 2-DE database:  NDKB_HUMAN NDKB_HUMAN General information about the entry View entry in simple text format Entry name NDKB_HUMAN Primary accession number P22392 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Nucleoside diphosphate kinase B; Short=NDK B; Short=NDP kinase B; EC=2.7.4.6; AltName: Full=C-myc purine-binding transcription factor PUF; AltName: Full=Histidine protein kinase NDKB; EC=2.7.13.3; AltName: Full=nm23-H2;. Gene name Name=NME2 Synonyms=NM23B Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0573: pI=5.64; Mw=19276 PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-1075: pI=8.32; Mw=16738 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1330: pI=8.41; Mw=16760 Cross-references UniProtKB/Swiss-Prot P22392; NDKB_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name NDKB_HUMAN Primary accession number P22392 Secondary accession number(s) A8MWA3 Q1WM23 Q6LCT6 Sequence was last modified on  August 1, 1991 (version 1) Annotations were last modified on  March 15, 2017 (version 203) Name and origin of the protein Description RecName: Full=Nucleoside diphosphate kinase B; Short=NDK B; Short=NDP kinase B; EC=2.7.4.6; AltName: Full=C-myc purine-binding transcription factor PUF; AltName: Full=Histidine protein kinase NDKB; EC=2.7.13.3; AltName: Full=nm23-H2; Gene name Name=NME2 Synonyms=NM23B Encoded on Name=NME2; Synonyms=NM23B Keywords 3D-structure; Activator; Alternative splicing; ATP-binding; Cell projection; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Kinase; Magnesium; Metal-binding; Nucleotide metabolism; Nucleotide-binding; Nucleus; Reference proteome; Transcription; Transcription regulation; Transferase. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X58965; CAB37870.1; -; mRNA EMBL M36981; AAA36369.1; -; mRNA EMBL L16785; AAA60228.1; -; mRNA EMBL DQ109675; AAZ82097.1; -; mRNA EMBL AC005839; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC002476; AAH02476.1; -; mRNA EMBL BC133029; AAI33030.1; -; mRNA EMBL BC133031; AAI33032.1; -; mRNA EMBL U29200; AAA86745.1; -; Genomic_DNA CCDS CCDS11580.1; -. [P22392-1]; . PIR A49798; A49798; . RefSeq NP_001018146.1; NM_001018136.2. [P22392-2]; . RefSeq NP_001018147.1; NM_001018137.2. [P22392-1]; . RefSeq NP_001018148.1; NM_001018138.1. [P22392-1]; . RefSeq NP_001018149.1; NM_001018139.2. [P22392-1]; . RefSeq NP_002503.1; NM_002512.3. [P22392-1]; . UniGene Hs.463456; -; . PDB 1NSK; X-ray; 2.80 A; L/N/O/R/T/U=1-152 PDB 1NUE; X-ray; 2.00 A; A/B/C/D/E/F=2-152 PDB 3BBB; X-ray; 1.30 A; A/B/C/D/E/F=2-152 PDB 3BBC; X-ray; 1.70 A; A/B/C/D/E/F=2-152 PDB 3BBF; X-ray; 1.70 A; A/B/C/D/E/F=2-152 PDBsum 1NSK; -; . PDBsum 1NUE; -; . PDBsum 3BBB; -; . PDBsum 3BBC; -; . PDBsum 3BBF; -; . ProteinModelPortal P22392; -; . SMR P22392; -; . BioGrid 110895; 83; . BioGrid 576341; 45; . DIP DIP-50179N; -; . IntAct P22392; 20; . MINT MINT-1429922; -; . STRING 9606.ENSP00000376886; -; . ChEMBL CHEMBL2160; -; . DrugBank DB00718; Adefovir Dipivoxil; . DrugBank DB04315; Guanosine-5'-Diphosphate; . DrugBank DB00709; Lamivudine; . DrugBank DB00300; Tenofovir; . iPTMnet P22392; -; . PhosphoSitePlus P22392; -; . SwissPalm P22392; -; . BioMuta NME2; -; . DMDM 127983; -; . DOSAC-COBS-2DPAGE P22392; -; . OGP P22392; -; . UCD-2DPAGE P22392; -; . EPD P22392; -; . PaxDb P22392; -; . PeptideAtlas P22392; -; . PRIDE P22392; -; . TopDownProteomics P22392-1; -. [P22392-1]; . TopDownProteomics P22392-2; -. [P22392-2]; . DNASU 4831; -; . DNASU 654364; -; . Ensembl ENST00000393190; ENSP00000376886; ENSG00000243678. [P22392-1]; . Ensembl ENST00000503064; ENSP00000426901; ENSG00000243678. [P22392-1]; . Ensembl ENST00000512737; ENSP00000421064; ENSG00000243678. [P22392-1]; . Ensembl ENST00000513177; ENSP00000425581; ENSG00000243678. [P22392-1]; . Ensembl ENST00000514264; ENSP00000426976; ENSG00000243678. [P22392-1]; . GeneID 4831; -; . GeneID 654364; -; . KEGG hsa:4831; -; . KEGG hsa:654364; -; . UCSC uc002itj.4; human. [P22392-1]; . CTD 4831; -; . CTD 654364; -; . DisGeNET 4831; -; . GeneCards NME2; -; . HGNC HGNC:7850; NME2; . HPA CAB002169; -; . HPA HPA041113; -; . MIM 156491; gene; . neXtProt NX_P22392; -; . OpenTargets ENSG00000011052; -; . OpenTargets ENSG00000243678; -; . PharmGKB PA162398077; -; . eggNOG KOG0888; Eukaryota; . eggNOG COG0105; LUCA; . GeneTree ENSGT00760000119146; -; . HOGENOM HOG000224564; -; . HOVERGEN HBG000423; -; . InParanoid P22392; -; . KO K00940; -; . PhylomeDB P22392; -; . TreeFam TF106373; -; . BioCyc MetaCyc:HS04463-MONOMER; -; . Reactome R-HSA-499943; Synthesis and interconversion of nucleotide di- and triphosphates; . Reactome R-HSA-6798695; Neutrophil degranulation; . SignaLink P22392; -; . SIGNOR P22392; -; . ChiTaRS NME2; human; . EvolutionaryTrace P22392; -; . GeneWiki NME1-NME2; -; . GeneWiki NME2; -; . PRO PR:P22392; -; . Proteomes UP000005640; Chromosome 17; . Bgee ENSG00000243678; -; . ExpressionAtlas P22392; baseline and differential; . Genevisible P22392; HS; . GO GO:0071944; C:cell periphery; IDA:UniProtKB; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:1904813; C:ficolin-1-rich granule lumen; TAS:Reactome; . GO GO:0030027; C:lamellipodium; IDA:HGNC; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0001726; C:ruffle; IDA:HGNC; . GO GO:0034774; C:secretory granule lumen; TAS:Reactome; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0003677; F:DNA binding; IEA:UniProtKB-KW; . GO GO:0046872; F:metal ion binding; IEA:UniProtKB-KW; . GO GO:0004550; F:nucleoside diphosphate kinase activity; IDA:UniProtKB; . GO GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC; . GO GO:0003700; F:transcription factor activity; sequence-specific DNA binding; TAS:UniProtKB GO GO:0007155; P:cell adhesion; TAS:HGNC; . GO GO:0006241; P:CTP biosynthetic process; IEA:InterPro; . GO GO:0006183; P:GTP biosynthetic process; IEA:InterPro; . GO GO:0007229; P:integrin-mediated signaling pathway; IDA:UniProtKB; . GO GO:0043066; P:negative regulation of apoptotic process; IMP:HGNC; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome; . GO GO:0009142; P:nucleoside triphosphate biosynthetic process; IDA:UniProtKB; . GO GO:0050679; P:positive regulation of epithelial cell proliferation; IMP:HGNC; . GO GO:0045618; P:positive regulation of keratinocyte differentiation; IMP:HGNC; . GO GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB; . GO GO:0045682; P:regulation of epidermis development; IMP:HGNC; . GO GO:0006355; P:regulation of transcription; DNA-templated; TAS:UniProtKB GO GO:0006351; P:transcription; DNA-templated; IEA:UniProtKB-KW GO GO:0006228; P:UTP biosynthetic process; IEA:InterPro; . HAMAP MF_00451; NDP_kinase; 1; . InterPro IPR001564; Nucleoside_diP_kinase; . InterPro IPR023005; Nucleoside_diP_kinase_AS; . Pfam PF00334; NDK; 1; . PRINTS PR01243; NUCDPKINASE; . SMART SM00562; NDK; 1; . PROSITE PS00469; NDP_KINASES; 1; .

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